How long does it typically take for liver function indices to return to normal postpartum?

The time it typically takes for liver function indices to return to normal postpartum is often around 3 weeks or less. This period is generally based on the physiological changes that occur during and after pregnancy. Pregnancy induces various hepatic adaptations, such as increased hepatic blood flow and alterations in liver enzyme levels, which are largely reverted after delivery as the body transitions back to its non-pregnant state.

Liver function tests, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST), usually show resolution of any transient increases that may have occurred during pregnancy within this timeframe. This fact supports the choice of 3 weeks or less as being the correct duration for the normalization of liver function indices, aligning with normal postpartum recovery expectations.

Longer durations, such as 6 weeks or 8 weeks, might be applicable if there were complications or ongoing liver diseases prior to or during pregnancy, but for the majority of healthy postpartum women, the liver function typically normalizes much sooner.