What chromosomal disorder is known to affect sexual development in males?

Klinefelter syndrome is a chromosomal disorder that specifically affects male individuals, typically resulting from the presence of an extra X chromosome (47,XXY instead of the typical 46,XY). This additional chromosome can lead to various physical and developmental characteristics, particularly regarding sexual development. Males with Klinefelter syndrome may experience reduced testosterone levels, which can affect testicular development, sexual maturity, and fertility.

These males often have taller stature and may develop less muscular bodies along with breast tissue development. This condition can also lead to learning difficulties and social challenges, although physically, many individuals may appear relatively normal. The disorder is significant in the context of sexual development because it directly influences the typical trajectory of male puberty and reproductive health.

The other chromosomal disorders listed affect different aspects of development or do not specifically target male sexual development in the same direct manner that Klinefelter syndrome does. For instance, Turner syndrome primarily affects females, while Down syndrome and Jacobs syndrome involve different chromosomal configurations and are not solely focused on male sexual development.